OFF HOLLYWOOD & VINE imagines the story of Travis, a teenage runaway living on the streets of Los Angeles and hustling for a living. Life for Travis is unbearably hard, and on a desperate night he decides to end it for good. As he closes in on his own death, a 6'4" transsexual named Mabel enters into his life and offers to help him commit the act. In a poignant twist, Mabel's unusual proposition ends up igniting the spark in Travis' life rather than extinguishing it.